Tissue Specificity | |
Post Translational Modifications | Phosphorylation at Ser-185 by CK2 has been shown to decrease enzymatic activity and may contribute to secretion by a non-classical secretory pathway. ISGylated. |
Function | In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis. Besides it's role as a glycolytic enzyme, also acts as a secreted cytokine: acts as an angiogenic factor (AMF) that stimulates endothelial cell motility. Acts as a neurotrophic factor, neuroleukin, for spinal and sensory neurons. It is secreted by lectin-stimulated T-cells and induces immunoglobulin secretion. |
Protein Name | Glucose-6-Phosphate IsomeraseGpiAutocrine Motility FactorAmfNeuroleukinNlkPhosphoglucose IsomerasePgiPhosphohexose IsomerasePhi |
Database Links | Reactome: R-RNO-5628897Reactome: -RNO-6798695Reactome: -RNO-70171Reactome: -RNO-70263 |
Cellular Localisation | CytoplasmSecreted |
Alternative ELISA Names | Glucose-6-Phosphate Isomerase ELISA kitGpi ELISA kitAutocrine Motility Factor ELISA kitAmf ELISA kitNeuroleukin ELISA kitNlk ELISA kitPhosphoglucose Isomerase ELISA kitPgi ELISA kitPhosphohexose Isomerase ELISA kitPhi ELISA kitGpi ELISA kit |
output | |
Information sourced from Uniprot.org