Recombinant Rat Follistatin/FST Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 45-50kDa.

Rat Follistatin/FST protein (Recombinant) (No-Tag) (STJP002937)

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STJP002937
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Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation: Unconjugated
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: <0.01 EU/Mu g of the protein by LAL method.
Immunoreactivity: Measured by its ability to neutralize Activin-mediated inhibition on MPC-11 cell proliferation. The ED50 for this effect is 23.68-94.70 ng/mL, corresponding to a specific activity of 1.06×104~4.22×104 units/mg in the
Gene Symbol: Fst
Gene ID: 24373
Uniprot ID: FST_RAT
Immunogen Region: Met1-Trp344
Immunogen: Recombinant Rat Follistatin/FST Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Met1-Trp344) of Rat Follistatin/FST (Accession #NP_036693.1) fused with a His tag at the C-terminus.
Immunogen Sequence: MTARGAAGRCPSSTWLGSRL LLVCLLMSRSIAKEVSEHCS HMIGNGHLKVLQQLIDSQME TSCQIAFEFVDQEQLDDPVC YLKKAFFLVQDIIDETMRFK DNTPNANATERLQELSNNLN SCFTKDYEEQNKACVRTFHE TPLQLLEKIKNFFNETKNLL EKDWNIFTKNCNNSFAKCSS RDVVTKP
Function Multifunctional regulatory protein whose primary function is to antagonize members of the transforming growth factor beta (TGF-beta) superfamily including activin, myostatin, GDF11 or bone morphogenetic proteins (BMPs). Mechanistically, binds to these ligands in the extracellular space, blocking their type II receptor-binding site to inhibit downstream signaling. Plays an essential role in muscle fiber formation and growth both by preventing the repressive effects of myostatin and through SMAD3/AKT/mTOR signaling independently of myostatin. Also promotes neural differentiation by antagonizing the action BMP4. Acts as a specific inhibitor of the biosynthesis and secretion of pituitary follicle stimulating hormone (FSH) by sequestering activin A/INHBA. On the other hand, translocates into the nucleus where it down-regulates rRNA synthesis and ribosome biogenesis to maintain cellular energy homeostasis by binding to rDNA.
Protein Name Follistatin
Fs
Activin-Binding Protein
Database Links Reactome: R-RNO-2473224
Cellular Localisation Secreted
Nucleus
Nucleolus
Alternative Protein Names Follistatin protein
Fs protein
Activin-Binding Protein protein
Fst protein

Information sourced from Uniprot.org

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