| Tissue Specificity | Expressed in the liver and brain (at protein level). Highest activity is found in the liver and adrenals followed by the testes and other organs, absent in adipose tissue. |
| Post Translational Modifications | |
| Function | Involved in the biosynthesis of highly unsaturated fatty acids (HUFA) from the essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3) precursors, acting as a fatty acyl-coenzyme A (CoA) desaturase that introduces a cis double bond at carbon 6 of the fatty acyl chain. Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma-linoleate (GLA) (18:3n-6) and stearidonate (18:4n-3), respectively. Subsequently, in the biosynthetic pathway of HUFA n-3 series, it desaturates tetracosapentaenoate (24:5n-3) to tetracosahexaenoate (24:6n-3), which is then converted to docosahexaenoate (DHA)(22:6n-3), an important lipid for nervous system function. It can also desaturate (11E)-octadecenoate (trans-vaccenoate) at carbon 6 generating (6Z,11E)-octadecadienoate. In addition to Delta-6 activity, this enzyme exhibits Delta-8 activity with slight biases toward n-3 fatty acyl-CoA substrates. |
| Protein Name | Acyl-Coa 6-DesaturaseDelta(6 Fatty Acid DesaturaseD6dDelta(6 DesaturaseDelta-6 DesaturaseFatty Acid Desaturase 2 |
| Database Links | Reactome: R-RNO-2046105Reactome: -RNO-2046106 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinMicrosome Membrane |
| Alternative ELISA Names | Acyl-Coa 6-Desaturase ELISA kitDelta(6 Fatty Acid Desaturase ELISA kitD6d ELISA kitDelta(6 Desaturase ELISA kitDelta-6 Desaturase ELISA kitFatty Acid Desaturase 2 ELISA kitFads2 ELISA kitFadsd6 ELISA kit |
| output | |
Information sourced from Uniprot.org
