| Host: |
HEK293 cells |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: |
Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: |
<0.1 EU/Mu g of the protein by LAL method. |
| Immunoreactivity: |
Measured in a cell proliferation assay using TF-1 Human erythroleukemic cells. The ED50 for this effect is 0.7-2.8 ng/mL, corresponding to a specific activity of 3.57×105~1.43×106 units/mg. |
| Gene Symbol: |
Epo |
| Gene ID: |
24335 |
| Uniprot ID: |
EPO_RAT |
| Immunogen Region: |
Ala27-Arg192 |
| Immunogen: |
Recombinant Rat Erythropoietin/EPO Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Ala27-Arg192) of Rat Erythropoietin/EPO (Accession #NP_058697.1) fused with a His tag at the C-terminus. |
| Immunogen Sequence: |
ACGPGRGFGKRQHPKKLTPL AYKQFIPNVAEKTLGASGRY EGKITRNSERFKELTPNYNP DIIFKDEENTGADRLMTQRC KDKLNALAISVMNQWPGVKL RVTEGWDEDGHHSEESLHYE GRAVDITTSDRDRSKYGMLA RLAVEAGFDWVYYESKARIH CSVKAENSVAAKSDG |
| Tissue Specificity | Produced by kidney or liver of adult mammals and by liver of fetal or neonatal mammals. |
| Function | Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass. Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3. |
| Protein Name | Erythropoietin |
| Database Links | Reactome: R-RNO-9027276Reactome: -RNO-9027284 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Erythropoietin proteinEpo protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
