Rat EDN1 (Endothelin 1) Competitive ELISA Kit (STJE0008575)
SPECIFICATIONS
General Information
| Short Description | This EDN1 Competitive ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Rat |
| Sensitivity | 2.19pg/mL |
| Detection Limit | 7.81-500pg/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 2.5 hrs |
Target Information
| Gene Symbol | Edn1 |
| Gene ID | 24323 |
| Uniprot ID | EDN1_RAT |
| Sample Type | serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
Additional Info
| Tissue Specificity | |
| Post Translational Modifications | |
| Function | Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells. Also binds the DEAR/FBXW7-AS1 receptor. Promotes mesenteric arterial wall remodeling via activation of ROCK signaling and subsequent colocalization of NFATC3 with F-actin filaments. NFATC3 then translocates to the nucleus where it subsequently promotes the transcription of the smooth muscle hypertrophy and differentiation marker ACTA2. |
| Protein Name | Endothelin-1Et-1Preproendothelin-1Ppet1 Cleaved Into - Big Endothelin-1 |
| Database Links | Reactome: R-RNO-375276Reactome: -RNO-416476 |
| Cellular Localisation | Secreted |
| Alternative ELISA Names | Endothelin-1 ELISA kitEt-1 ELISA kitPreproendothelin-1 ELISA kitPpet1 Cleaved Into - Big Endothelin-1 ELISA kitEdn1 ELISA kit |
| output |
Information sourced from Uniprot.org