Rat EDN1 (Endothelin 1) Competitive ELISA Kit Kit (STJE0008575)

Rat EDN1 (Endothelin 1) Competitive ELISA Kit Kit (STJE0008575)

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STJE0008575
£406.50 - £552.50
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Applications: ELISA
Reactivity: Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 2.19pg/mL
Detection Limit: 7.81-500pg/mL
Short Description : This EDN1 Competitive ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids..
Storage Instruction: Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 2.5 hrs
Gene Symbol: Edn1
Gene ID: 24323
Uniprot ID: EDN1_RAT
Sample Type: serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.
Tissue Specificity
Post Translational Modifications
Function Endothelins are endothelium-derived vasoconstrictor peptides. Probable ligand for G-protein coupled receptors EDNRA and EDNRB which activates PTK2B, BCAR1, BCAR3 and, GTPases RAP1 and RHOA cascade in glomerular mesangial cells. Also binds the DEAR/FBXW7-AS1 receptor. Promotes mesenteric arterial wall remodeling via activation of ROCK signaling and subsequent colocalization of NFATC3 with F-actin filaments. NFATC3 then translocates to the nucleus where it subsequently promotes the transcription of the smooth muscle hypertrophy and differentiation marker ACTA2.
Protein Name Endothelin-1
Et-1
Preproendothelin-1
Ppet1 Cleaved Into - Big Endothelin-1
Database Links Reactome: R-RNO-375276
Reactome: -RNO-416476
Cellular Localisation Secreted
Alternative ELISA Names Endothelin-1 ELISA kit
Et-1 ELISA kit
Preproendothelin-1 ELISA kit
Ppet1 Cleaved Into - Big Endothelin-1 ELISA kit
Edn1 ELISA kit
output

Information sourced from Uniprot.org

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