Tissue Specificity | Expressed in colon, duodenum, rectum and thyroid. |
Post Translational Modifications | N-glycosylated. |
Function | Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain. |
Protein Name | Dual Oxidase 2Large Nox 2Long Nox 2Nadh/Nadph Thyroid Oxidase Thox2Thyroid Oxidase 2 |
Database Links | Reactome: R-RNO-209968 |
Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinCell JunctionLocalizes To The Apical Membrane Of Epithelial CellsLocalizes On Internal Membrane Structures Under Resting ConditionsTranslocates To The Plasma Membrane And Cell-Cell Junctions Upon Challenge With Enteric Pathogens |
Alternative ELISA Names | Dual Oxidase 2 ELISA kitLarge Nox 2 ELISA kitLong Nox 2 ELISA kitNadh/Nadph Thyroid Oxidase Thox2 ELISA kitThyroid Oxidase 2 ELISA kitDuox2 ELISA kitLnox2 ELISA kitThox2 ELISA kit |
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Information sourced from Uniprot.org