Rat DIO2 (Deiodinase, Iodothyronine, Type II) Sandwich ELISA Kit Ready-To-Use Kit (STJE0014816)

Rat DIO2 (Deiodinase, Iodothyronine, Type II) Sandwich ELISA Kit Ready-To-Use Kit (STJE0014816)

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STJE0014816
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Applications: ELISA
Reactivity: Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Sensitivity: 0.24ng/mL
Detection Limit: 0.781-50ng/mL
Short Description : This DIO2 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat tissue homogenates or other biological fluids..
Storage Instruction: The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit.
Assay Time: 3 hrs
Gene Symbol: Dio2
Gene ID: 65162
Uniprot ID: IOD2_RAT
Immunogen Region: Ready-To-Use
Sample Type: tissue homogenates or other biological fluids.
Tissue Specificity Expressed in cerebral cortex, cerebellum, pituitary gland, mostly in anterior pituitary gland, and pineal gland, as well as in brown adipose tissue (BAT).
Post Translational Modifications Ubiquitinated by MARCHF6, leading to its degradation by the proteasome. Deubiquitinated by USP20 and USP33.
Function Plays a crucial role in the metabolism of thyroid hormones (TH) and has specific roles in TH activation and inactivation by deiodination. Catalyzes the deiodination of L-thyroxine (T4) to 3,5,3'-triiodothyronine (T3) and 3',5'-diiodothyronine (3',5'-T2) to 3'-monoiodothyronine (3'-T1) via outer-ring deiodination (ORD). Catalyzes the deiodination of 3,3',5'-triiodothyronine (rT3) to 3,3'-diiodothyronine (3,3'-T2) via ORD. Catalyzes the phenolic ring deiodinations of 3,3',5'-triiodothyronamine and 3',5'- diiodothyronamine.
Protein Name Type Ii Iodothyronine Deiodinase
5dii
Dioii
Type 2 Di
Type-Ii 5'-Deiodinase
Database Links Reactome: R-RNO-350864
Cellular Localisation Endoplasmic Reticulum Membrane
Single-Pass Type Iii Membrane Protein
Alternative ELISA Names Type Ii Iodothyronine Deiodinase ELISA kit
5dii ELISA kit
Dioii ELISA kit
Type 2 Di ELISA kit
Type-Ii 5'-Deiodinase ELISA kit
Dio2 ELISA kit
Itdi2 ELISA kit
Txdi2 ELISA kit
output

Information sourced from Uniprot.org

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