Tissue Specificity | Expressed in cerebral cortex, cerebellum, pituitary gland, mostly in anterior pituitary gland, and pineal gland, as well as in brown adipose tissue (BAT). |
Post Translational Modifications | Ubiquitinated by MARCHF6, leading to its degradation by the proteasome. Deubiquitinated by USP20 and USP33. |
Function | Catalyzes the deiodination of T4 (3,5,3',5'-tetraiodothyronine) into T3 (3,5,3'-triiodothyronine). Essential for providing the brain with appropriate levels of T3 during the critical period of development. |
Protein Name | Type Ii Iodothyronine Deiodinase5diiDioiiType 2 DiType-Ii 5'-Deiodinase |
Database Links | Reactome: R-RNO-350864 |
Cellular Localisation | MembraneSingle-Pass Membrane Protein |
Alternative ELISA Names | Type Ii Iodothyronine Deiodinase ELISA kit5dii ELISA kitDioii ELISA kitType 2 Di ELISA kitType-Ii 5'-Deiodinase ELISA kitDio2 ELISA kitItdi2 ELISA kitTxdi2 ELISA kit |
output | |
Information sourced from Uniprot.org