rat Cyclophilin F/PPIF protein (Recombinant) (His-Tag) (STJP019193)

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STJP019193
£134.50 - £738.50
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Host: E.coli
Applications: SDS-PAGE
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-rat Cyclophilin F/PPIF-His-Tag protein was developed from e.coli and has a target region of His-Tag. For use in research applications.
Formulation: Liquid in phosphate-Buffered Saline (pH 7.4) containing 10% Glycerol, 1mM DTT
Concentration: 1 mg/mL
Storage Instruction: For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles.
Gene Symbol: Ppif
Gene ID: 282819
Uniprot ID: PPIF_RAT
Immunogen Region: 30-206aa
Accession Number: NP_758443
Immunogen: Rat
Immunogen Sequence: MGSSHHHHHH SSGLVPRGSH MGSCSDGGAR GANSSSQNPL VYLDVGADGQ PLGRVVLELK ADVVPKTAEN FRALCTGEKG FGYKGSTFHR VIPAFMCQAG DFTNHNGTGG KSIYGSRFPD ENFTLKHVGP GVLSMANAGP NTNGSQFFIC TIKTDWLDGK HVVFGHVKEG MDVVKKIESF GSKSGKTSKK IVITDCGQLS
Post Translational Modifications Acetylated at Lys-166.deacetylated at Lys-166 by SIRT3.
Function PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Involved in regulation of the mitochondrial permeability transition pore (mPTP). It is proposed that its association with the mPTP is masking a binding site for inhibiting inorganic phosphate (Pi) and promotes the open probability of the mPTP leading to apoptosis or necrosis.the requirement of the PPIase activity for this function is debated. In cooperation with mitochondrial p53/TP53 is involved in activating oxidative stress-induced necrosis. Involved in modulation of mitochondrial membrane F(1)F(0) ATP synthase activity and regulation of mitochondrial matrix adenine nucleotide levels. Has anti-apoptotic activity independently of mPTP and in cooperation with BCL2 inhibits cytochrome c-dependent apoptosis.
Protein Name Peptidyl-Prolyl Cis-Trans Isomerase F - Mitochondrial
Ppiase F
Cyclophilin D
Cyp-D
Cypd
Cyclophilin F
Rotamase F
Database Links
Cellular Localisation Mitochondrion Matrix
Alternative Protein Names Peptidyl-Prolyl Cis-Trans Isomerase F - Mitochondrial protein
Ppiase F protein
Cyclophilin D protein
Cyp-D protein
Cypd protein
Cyclophilin F protein
Rotamase F protein
Ppif protein

Information sourced from Uniprot.org

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