| Host: | Goat/Goat |
| Applications: | ELISA |
| Reactivity: | Rat |
| Note: | FOR SCIENTIFIC EDUCATIONAL RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR OTHER MEDICAL APPLICATIONS. |
| Short Description : | This CX3CL1 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the Sandwich ELISA. |
| Clonality : | Polyclonal/Polyclonal |
| Conjugation: | Unconjugated/Biotin |
| Formulation: | Capture Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4. Detection Buffer: PBS with 0.04% Proclin 300, 50% glycerol, pH 7.4. |
| Purification: | Capture Purification: Antigen Affinity. Detection Purification: Antigen Affinity. |
| Concentration: | 0.5 mg/mL |
| Storage Instruction: | Store at-20°C for long term, and avoid freeze-thaw cycles. |
| Gene Symbol: | Cx3cl1 |
| Gene ID: | 89808 |
| Uniprot ID: | X3CL1_RAT |
| Immunogen: | Capture immunogen: Recombinant Rat CX3CL1 protein. Detection Immunogen: Recombinant Rat CX3CL1 protein. |
| Post Translational Modifications | A soluble short form may be released by proteolytic cleavage from the long membrane-anchored form. |
| Function | Chemokine that acts as a ligand for both CX3CR1 and integrins ITGAV:ITGB3 and ITGA4:ITGB1. The CX3CR1-CX3CL1 signaling exerts distinct functions in different tissue compartments, such as immune response, inflammation, cell adhesion and chemotaxis. Regulates leukocyte adhesion and migration processes at the endothelium. Can activate integrins in both a CX3CR1-dependent and CX3CR1-independent manner. In the presence of CX3CR1, activates integrins by binding to the classical ligand-binding site (site 1) in integrins. In the absence of CX3CR1, binds to a second site (site 2) in integrins which is distinct from site 1 and enhances the binding of other integrin ligands to site 1. Processed fractalkine: The soluble form is chemotactic for T-cells and monocytes, but not for neutrophils. Fractalkine: The membrane-bound form promotes adhesion of those leukocytes to endothelial cells. |
| Protein Name | Fractalkine C-X3-C Motif Chemokine 1 Cx3c Membrane-Anchored Chemokine Neurotactin Small-Inducible Cytokine D1 Cleaved Into - Processed Fractalkine |
| Database Links | Reactome: R-RNO-380108 Reactome: -RNO-418594 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein Processed Fractalkine: Secreted |
| Alternative Antibody Pair Names | Fractalkine antibody pair C-X3-C Motif Chemokine 1 antibody pair Cx3c Membrane-Anchored Chemokine antibody pair Neurotactin antibody pair Small-Inducible Cytokine D1 Cleaved Into - Processed Fractalkine antibody pair Cx3cl1 antibody pair Acc1 antibody pair Fkn antibody pair Scyd1 antibody pair |
Information sourced from Uniprot.org