| Post Translational Modifications | N-glycosylated. Sulfation increases the affinity for both monomeric and dimeric CCL2 with stronger binding to the monomeric form. Binding of sulfated CCR2 to CCL2 promotes conversion of CCL2 from dimer to monomer. |
| Function | Key functional receptor for CCL2 but can also bind CCL7 and CCL12. Its binding with CCL2 on monocytes and macrophages mediates chemotaxis and migration induction through the activation of the PI3K cascade, the small G protein Rac and lamellipodium protrusion. Also acts as a receptor for the beta-defensin DEFB106A/DEFB106B. Regulates the expression of T-cell inflammatory cytokines and T-cell differentiation, promoting the differentiation of T-cells into T-helper 17 cells (Th17) during inflammation. Facilitates the export of mature thymocytes by enhancing directional movement of thymocytes to sphingosine-1-phosphate stimulation and up-regulation of S1P1R expression.signals through the JAK-STAT pathway to regulate FOXO1 activity leading to an increased expression of S1P1R. Plays an important role in mediating peripheral nerve injury-induced neuropathic pain. Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-dependent phosphorylation of GRIN2B/NMDAR2B. Mediates the recruitment of macrophages and monocytes to the injury site following brain injury. |
| Protein Name | C-C Chemokine Receptor Type 2C-C Ckr-2Cc-Ckr-2Ccr-2Ccr2Cd Antigen Cd192 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinThe Chemoattractant Receptors Are Distributed Throughout The Cell SurfaceAfter Stimulation With A LigandSuch As Ccl2They Are Rapidly Recruited Into Microdomain Clusters At The Cell Membrane |
| Alternative Protein Names | C-C Chemokine Receptor Type 2 proteinC-C Ckr-2 proteinCc-Ckr-2 proteinCcr-2 proteinCcr2 proteinCd Antigen Cd192 proteinCcr2 proteinCmkbr2 protein |
Information sourced from Uniprot.org
