| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 0.1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | Crp |
| Gene ID: | 25419 |
| Uniprot ID: | CRP_RAT |
| Immunogen: | Recombinant Rat C-Reactive Protein/CRP Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (His20-Ser230) of rat C-Reactive Protein/CRP (Accession #NP_058792.1) fused with a 6×His tag at the C-terminus |
| Immunogen Sequence: | HEDMSKQAFVFPGVSATAYV SLEAESKKPLEAFTVCLYAH ADVSRSFSIFSYATKTSFNE ILLFWTRGQGFSIAVGGPEI LFSASEIPEVPTHICATWES ATGIVELWLDGKPRVRKSLQ KGYIVGTNASIILGQEQDSY GGGFDANQSLVGDIGDVNMW DFVLSPEQINAVYVGRVFSP NVLNWRALKYETHGDVFIKP QLWPLTDCCES |
| Post Translational Modifications | The last two cysteines are involved either in interchain disulfide bonds or in an intrachain bond. |
| Function | Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells. |
| Protein Name | C-Reactive Protein |
| Database Links | Reactome: R-RNO-173623 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | C-Reactive Protein proteinCrp proteinPtx1 protein |
Information sourced from Uniprot.org