Recombinant Rat ALK-1/ACVRL1 Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 45-60 kDa.

Rat ALK-1/ACVRL1 protein (Recombinant) (N-His) (STJP002996)

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STJP002996
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Host: Pichia
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from 0.22 Mu m filtered solution in PBS (pH 7.4). Normally 8% Trehalose is added as protectant before lyophilisation.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 0.01 EU/Mu g of the protein by LAL method
Immunoreactivity: Measured by its binding ability in a functional ELISA. Immobilized Rat ALK-1at 4 Mu g/mL (100 Mu L/well) can bind Human ACVR2B with a linear range of 20-989.42 ng/mL.
Gene Symbol: Acvrl1
Gene ID: 25237
Uniprot ID: ACVL1_RAT
Immunogen Region: Lys21-Ala118
Immunogen: Recombinant Recombinant Rat ALK-1/ACVRL1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Lys21-Ala118) of Rat ALK-1/ACVRL1 (Accession #NP_071886.1) fused with a hFc tag at the C-terminus.
Immunogen Sequence: QPDGPNASTCCYVKKQKIPK RNLKSYRRITSSRCPWEAVI FKTKKGMEVCAEAHQKWVEE AIAYLDMKTPTPKP
Tissue Specificity Urogenital ridge, testis, ovary, brain and lung. In lung, found exclusively in pulmonary vessels of all sizes. Also expressed in aorta, vena cava and certain blood vessels of kidney, spleen, heart and intestine. For most blood vessels, a higher level of expression is found in endothelium than in adjacent smooth muscle.
Function Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well.
Protein Name Activin Receptor Type-1-Like
Serine/Threonine-Protein Kinase Receptor R3
Skr3
Tgf-B Superfamily Receptor Type I
Tsr-I
Database Links Reactome: R-RNO-201451
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Alternative Protein Names Activin Receptor Type-1-Like protein
Serine/Threonine-Protein Kinase Receptor R3 protein
Skr3 protein
Tgf-B Superfamily Receptor Type I protein
Tsr-I protein
Acvrl1 protein
Acvrlk1 protein

Information sourced from Uniprot.org

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