| Tissue Specificity | Detected in liver, ovary, kidney, testicle, lung and embryo. |
| Post Translational Modifications | Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Can also be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs. N- and C-glycosylations can also facilitate secretion. O-glycosylated proteoglycan. Contains chondroitin sulfate. May be cleaved by a furin endopeptidase. The precursor is sequentially processed. |
| Function | Metalloprotease that may play a role in the degradation of COMP. |
| Protein Name | A Disintegrin And Metalloproteinase With Thrombospondin Motifs 7Adam-Ts 7Adam-Ts7Adamts-7Compase |
| Database Links | Reactome: R-RNO-5173214 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular MatrixAlso Found Associated With The External Cell Surface |
| Alternative ELISA Names | A Disintegrin And Metalloproteinase With Thrombospondin Motifs 7 ELISA kitAdam-Ts 7 ELISA kitAdam-Ts7 ELISA kitAdamts-7 ELISA kitCompase ELISA kitAdamts7 ELISA kit |
| output | |
Information sourced from Uniprot.org
