Rat ADAMTS4 (A Disintegrin And Metalloproteinase With Thrombospondin 4) Sandwich ELISA Kit Ready-To-Use Kit (STJE0013278)
SPECIFICATIONS
General Information
| Short Description | This ADAMTS4 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in rat serum, plasma, tissue homogenates or other biological fluids.. |
| Applications | ELISA |
| Reactivity | Rat |
| Sensitivity | 1.15ng/mL |
| Detection Limit | 3.12-200ng/mL |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Storage Instruction | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time | 3 hrs |
Target Information
| Gene Symbol | Adamts4 |
| Gene ID | 66015 |
| Uniprot ID | ATS4_RAT |
| Immunogen Region | Ready-To-Use |
| Sample Type | serum, plasma, tissue homogenates or other biological fluids. |
Additional Info
| Tissue Specificity | Brain specific. |
| Post Translational Modifications | The precursor is cleaved by a furin endopeptidase. Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Can also be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion. |
| Function | Cleaves aggrecan, a cartilage proteoglycan, at the '392-Glu-|-Ala-393' site and may be involved in its turnover. Also cleaves COMP. May play an important role in the destruction of aggrecan in arthritic diseases. |
| Protein Name | A Disintegrin And Metalloproteinase With Thrombospondin Motifs 4Adam-Ts 4Adam-Ts4Adamts-4Aggrecanase-1 |
| Database Links | Reactome: R-RNO-1474228Reactome: -RNO-5173214 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative ELISA Names | A Disintegrin And Metalloproteinase With Thrombospondin Motifs 4 ELISA kitAdam-Ts 4 ELISA kitAdam-Ts4 ELISA kitAdamts-4 ELISA kitAggrecanase-1 ELISA kitAdamts4 ELISA kit |
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Information sourced from Uniprot.org