| Applications: |
WB |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
PTBP2 Positive Control for STJ506039 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: |
Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
PTBP2 |
| Gene ID: |
58155 |
| Uniprot ID: |
PTBP2_HUMAN |
| Specificity: |
This is positive control is recommended for use in combination with PTBP2 antibody STJ506039. |
| Immunogen: |
Purified Polypyrimidine tract-binding protein 2/PTBP2. |
| Tissue Specificity | Mainly expressed in brain although also detected in other tissues like heart and skeletal muscle. Isoform 1 and isoform 2 are specifically expressed in neuronal tissues. Isoform 3 and isoform 4 are expressed in non-neuronal tissues. Isoform 5 and isoform 6 are truncated forms expressed in non-neuronal tissues. |
| Function | RNA-binding protein which binds to intronic polypyrimidine tracts and mediates negative regulation of exons splicing. May antagonize in a tissue-specific manner the ability of NOVA1 to activate exon selection. In addition to its function in pre-mRNA splicing, plays also a role in the regulation of translation. Isoform 5: Reduced affinity for RNA. |
| Peptide Name | Polypyrimidine Tract-Binding Protein 2Neural Polypyrimidine Tract-Binding ProteinNeurally-Enriched Homolog Of PtbPtb-Like Protein |
| Cellular Localisation | Nucleus |
| Alternative Peptide Names | Polypyrimidine Tract-Binding Protein 2 proteinNeural Polypyrimidine Tract-Binding Protein proteinNeurally-Enriched Homolog Of Ptb proteinPtb-Like Protein proteinPTBP2 proteinNPTB proteinPTB proteinPTBLP protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
