| Applications: | WB |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | PREX1 Positive Control for STJ502650 is synthetically produced from the sequence and is suitable for use in western blot applications. |
| Formulation: | Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is |
| Dilution Range: | WB: 1:500-1:750 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | PREX1 |
| Gene ID: | 57580 |
| Uniprot ID: | PREX1_HUMAN |
| Specificity: | This is positive control is recommended for use in combination with PREX1 antibody STJ502650. |
| Tissue Specificity | Mainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues. |
| Function | Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. |
| Peptide Name | Phosphatidylinositol 3 -4 -5-Trisphosphate-Dependent Rac Exchanger 1 ProteinP-Rex1Ptdins(3 -4 -5-Dependent Rac Exchanger 1 |
| Database Links | Reactome: R-HSA-193648Reactome: R-HSA-416482Reactome: R-HSA-8980692Reactome: R-HSA-9013026Reactome: R-HSA-9013106Reactome: R-HSA-9013148Reactome: R-HSA-9013149Reactome: R-HSA-9013404Reactome: R-HSA-9013406Reactome: R-HSA-9013408Reactome: R-HSA-9013409Reactome: R-HSA-9013423 |
| Cellular Localisation | CytoplasmCytosolCell MembraneMainly CytosolicSome Amount Is Apparently Associated To The Plasma Membrane |
| Alternative Peptide Names | Phosphatidylinositol 3 -4 -5-Trisphosphate-Dependent Rac Exchanger 1 Protein proteinP-Rex1 proteinPtdins(3 -4 -5-Dependent Rac Exchanger 1 proteinPREX1 proteinKIAA1415 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance