| Applications: | Immunodepletion/Immunocompetition |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: | PREX1 Blocking Peptide for STJ502650 is synthetically produced from the 815-836 sequence and is suitable for use in western blot applications. |
| Formulation: | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | PREX1 |
| Gene ID: | 57580 |
| Uniprot ID: | PREX1_HUMAN |
| Immunogen Region: | 815-836 |
| Specificity: | This blocking peptide is recommended for use in combination with PREX1 antibody, STJ502650 |
| Immunogen: | Synthetic peptide corresponding to aino acid region 815-836 of Human PREX1. Peptide was covalently modified. Sequence: QEEDQADSAFPLLSLGPRLSLC |
| Tissue Specificity | Mainly expressed in peripheral blood leukocytes and brain. Expressed at intermediate level in spleen and lymph nodes, and weakly expressed in other tissues. |
| Function | Functions as a RAC guanine nucleotide exchange factor (GEF), which activates the Rac proteins by exchanging bound GDP for free GTP. Its activity is synergistically activated by phosphatidylinositol 3,4,5-trisphosphate and the beta gamma subunits of heterotrimeric G protein. May function downstream of heterotrimeric G proteins in neutrophils. |
| Peptide Name | Phosphatidylinositol 3 -4 -5-Trisphosphate-Dependent Rac Exchanger 1 Protein P-Rex1 Ptdins(3 -4 -5-Dependent Rac Exchanger 1 |
| Database Links | Reactome: R-HSA-193648 Reactome: R-HSA-416482 Reactome: R-HSA-8980692 Reactome: R-HSA-9013026 Reactome: R-HSA-9013106 Reactome: R-HSA-9013148 Reactome: R-HSA-9013149 Reactome: R-HSA-9013404 Reactome: R-HSA-9013406 Reactome: R-HSA-9013408 Reactome: R-HSA-9013409 Reactome: R-HSA-9013423 |
| Cellular Localisation | Cytoplasm Cytosol Cell Membrane Mainly Cytosolic Some Amount Is Apparently Associated To The Plasma Membrane |
| Alternative Peptide Names | Phosphatidylinositol 3 -4 -5-Trisphosphate-Dependent Rac Exchanger 1 Protein protein P-Rex1 protein Ptdins(3 -4 -5-Dependent Rac Exchanger 1 protein PREX1 protein KIAA1415 protein |
Information sourced from Uniprot.org