PICK1 Blocking Peptide for STJ505934 peptide (STJ505720)
SPECIFICATIONS
ImmunogenSynthetic peptide taken within amino acid region 330-380 on human PRKCA-binding protein/PICK1 protein.
General Information
| Short Description | PICK1 Blocking Peptide for STJ505934 is synthetically produced from the 330-380 sequence and is suitable for use in western blot applications. |
| Applications | Immunodepletion/Immunocompetition |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Formulation | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction | Store at-20ยฐC for long term storage. Avoid freeze-thaw cycles. |
Target Information
| Gene Symbol | PICK1 |
| Gene ID | 9463 |
| Uniprot ID | PICK1_HUMAN |
| Immunogen | Synthetic peptide taken within amino acid region 330-380 on human PRKCA-binding protein/PICK1 protein. |
| Immunogen Region | 330-380 |
| Specificity | This blocking peptide is recommended for use in combination with PICK1 antibody, STJ505934 |
Additional Info
| Post Translational Modifications | Phosphorylation at Thr-82 appears to inhibit the interaction with AMPA receptors. Palmitoylation on Cys-413 is essential for long-term synaptic depression (LTD). |
| Function | Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex.the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function. |
| Peptide Name | Prkca-Binding ProteinProtein Interacting With C Kinase 1Protein Kinase C-Alpha-Binding Protein |
| Database Links | Reactome: R-HSA-202733Reactome: R-HSA-416993 |
| Cellular Localisation | CytoplasmPerinuclear RegionMembranePeripheral Membrane ProteinLipid-AnchorPostsynaptic DensitySynapseSynaptosomeCytoskeletonAlso Membrane-AssociatedPresent At Excitatory Synapses |
| Alternative Peptide Names | Prkca-Binding Protein proteinProtein Interacting With C Kinase 1 proteinProtein Kinase C-Alpha-Binding Protein proteinPICK1 proteinPRKCABP protein |
Information sourced from Uniprot.org