| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
PDE5A Blocking Peptide is synthetically produced from the 825-875 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
PDE5A |
| Gene ID: |
8654 |
| Uniprot ID: |
PDE5A_HUMAN |
| Immunogen Region: |
825-875 |
| Immunogen: |
Synthetic peptide common to all PDE5A variants taken within amino acid region 825-875 on human PDE5A protein. |
| Tissue Specificity | Expressed in aortic smooth muscle cells, heart, placenta, skeletal muscle and pancreas and, to a much lesser extent, in brain, liver and lung. |
| Post Translational Modifications | Phosphorylation is regulated by binding of cGMP to the two allosteric sites. Phosphorylation by PRKG1 leads to its activation. |
| Function | Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides. This phosphodiesterase catalyzes the specific hydrolysis of cGMP to 5'-GMP. Specifically regulates nitric-oxide-generated cGMP. |
| Peptide Name | Cgmp-Specific 3' -5'-Cyclic PhosphodiesteraseCgmp-Binding Cgmp-Specific PhosphodiesteraseCgb-Pde |
| Database Links | Reactome: R-HSA-418457Reactome: R-HSA-445355Reactome: R-HSA-9013422 |
| Alternative Peptide Names | Cgmp-Specific 3' -5'-Cyclic Phosphodiesterase proteinCgmp-Binding Cgmp-Specific Phosphodiesterase proteinCgb-Pde proteinPDE5A proteinPDE5 protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
