PDE3B Blocking Peptide peptide (STJ504617)

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STJ504617-250
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Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : PDE3B Blocking Peptide is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Pde3b
Gene ID: 29516
Uniprot ID: PDE3B_RAT
Immunogen: Synthetic peptide corresponding to unique amino acid sequence on PDE3B gene.
Tissue Specificity Abundant in adipose tissues.
Post Translational Modifications Phosphorylation at Ser-279 mediates insulin-induced activation of PDE3B.
Function Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Regulates angiogenesis by inhibiting the cAMP-dependent guanine nucleotide exchange factor RAPGEF3 and downstream phosphatidylinositol 3-kinase gamma-mediated signaling. Controls cardiac contractility by reducing cAMP concentration in cardiocytes.
Peptide Name Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3b
Cgi Pde
Cyclic Gmp-Inhibited Phosphodiesterase B
Cgi-Pde B
Rcgipl
Database Links Reactome: R-RNO-165160
Reactome: -RNO-418555
Cellular Localisation Membrane
Multi-Pass Membrane Protein
Alternative Peptide Names Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3b protein
Cgi Pde protein
Cyclic Gmp-Inhibited Phosphodiesterase B protein
Cgi-Pde B protein
Rcgipl protein
Pde3b protein

Information sourced from Uniprot.org

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