Applications: | Immunodepletion/Immunocompetition |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | PDE3B Blocking Peptide is synthetically produced from the sequence and is suitable for use in western blot applications. |
Formulation: | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
Gene Symbol: | Pde3b |
Gene ID: | 29516 |
Uniprot ID: | PDE3B_RAT |
Immunogen: | Synthetic peptide corresponding to unique amino acid sequence on PDE3B gene. |
Tissue Specificity | Abundant in adipose tissues. |
Post Translational Modifications | Phosphorylation at Ser-279 mediates insulin-induced activation of PDE3B. |
Function | Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Regulates angiogenesis by inhibiting the cAMP-dependent guanine nucleotide exchange factor RAPGEF3 and downstream phosphatidylinositol 3-kinase gamma-mediated signaling. Controls cardiac contractility by reducing cAMP concentration in cardiocytes. |
Peptide Name | Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3b Cgi Pde Cyclic Gmp-Inhibited Phosphodiesterase B Cgi-Pde B Rcgipl |
Database Links | Reactome: R-RNO-165160 Reactome: -RNO-418555 |
Cellular Localisation | Membrane Multi-Pass Membrane Protein |
Alternative Peptide Names | Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3b protein Cgi Pde protein Cyclic Gmp-Inhibited Phosphodiesterase B protein Cgi-Pde B protein Rcgipl protein Pde3b protein |
Information sourced from Uniprot.org