| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Phospho-PDE3B Blocking Peptide is synthetically produced from the 260-310 sequence and is suitable for use in western blot applications. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
PDE3B |
| Gene ID: |
5140 |
| Uniprot ID: |
PDE3B_HUMAN |
| Immunogen Region: |
260-310 |
| Immunogen: |
Synthetic peptide taken within amino acid region 260-310 on human PDE3B protein. Selective only for PDE3B variant. |
| Tissue Specificity | Abundant in adipose tissues. |
| Post Translational Modifications | Phosphorylation at Ser-295 mediates insulin-induced activation of PDE3B. |
| Function | Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological process. Regulates angiogenesis by inhibiting the cAMP-dependent guanine nucleotide exchange factor RAPGEF3 and downstream phosphatidylinositol 3-kinase gamma-mediated signaling. Controls cardiac contractility by reducing cAMP concentration in cardiocytes. |
| Peptide Name | Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3bCgipde1Cgip1Cyclic Gmp-Inhibited Phosphodiesterase BCgi-Pde B |
| Database Links | Reactome: R-HSA-165160Reactome: R-HSA-418555 |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Peptide Names | Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3b proteinCgipde1 proteinCgip1 proteinCyclic Gmp-Inhibited Phosphodiesterase B proteinCgi-Pde B proteinPDE3B protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
