PDE3B Blocking Peptide for STJ502607 peptide (STJ505766)

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STJ505766-250
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Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : PDE3B Blocking Peptide for STJ502607 is synthetically produced from the 260-310 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: PDE3B
Gene ID: 5140
Uniprot ID: PDE3B_HUMAN
Immunogen Region: 260-310
Specificity: This blocking peptide is recommended for use in combination with PDE3B antibody, STJ502607
Immunogen: Synthetic peptide taken within amino acid region 260-310 on human PDE3B protein. Selective only for PDE3B variant.
Tissue Specificity Abundant in adipose tissues.
Post Translational Modifications Phosphorylation at Ser-295 mediates insulin-induced activation of PDE3B.
Function Cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological process. Regulates angiogenesis by inhibiting the cAMP-dependent guanine nucleotide exchange factor RAPGEF3 and downstream phosphatidylinositol 3-kinase gamma-mediated signaling. Controls cardiac contractility by reducing cAMP concentration in cardiocytes.
Peptide Name Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3b
Cgipde1
Cgip1
Cyclic Gmp-Inhibited Phosphodiesterase B
Cgi-Pde B
Database Links Reactome: R-HSA-165160
Reactome: R-HSA-418555
Cellular Localisation Membrane
Multi-Pass Membrane Protein
Alternative Peptide Names Cgmp-Inhibited 3' -5'-Cyclic Phosphodiesterase 3b protein
Cgipde1 protein
Cgip1 protein
Cyclic Gmp-Inhibited Phosphodiesterase B protein
Cgi-Pde B protein
PDE3B protein

Information sourced from Uniprot.org

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