PDE2A4 Positive Control peptide (STJ504611)

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STJ504611-5

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Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: PDE2A4 Positive Control is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Dilution Range: WB: 1:500
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: PDE2A
Gene ID: 5138
Uniprot ID: PDE2A_HUMAN
Tissue Specificity Widely expressed. Expressed in brain, with high expression observed in the corpus striatum. Also expressed in heart, placenta, lung, skeletal muscle, kidney and pancreas.
Function cGMP-activated cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher efficiency with cGMP compared to cAMP. Plays a role in cell growth and migration. Isoform PDE2A2: Regulates mitochondrial cAMP levels and respiration. Involved in the regulation of mitochondria morphology/dynamics and apoptotic cell death via local modulation of cAMP/PKA signaling in the mitochondrion, including the monitoring of local cAMP levels at the outer mitochondrial membrane and of PKA-dependent phosphorylation of DNM1L.
Peptide Name Cgmp-Dependent 3' -5'-Cyclic Phosphodiesterase
Cyclic Gmp-Stimulated Phosphodiesterase
Cgs-Pde
Cgspde
Database Links Reactome: R-HSA-418457
Reactome: R-HSA-418555
Cellular Localisation Isoform Pde2a3: Cell Membrane
Lipid-Anchor
Isoform Pde2a2: Mitochondrion Matrix
Mitochondrion Inner Membrane
Mitochondrion Outer Membrane
Isoform Pde2a1: Cytoplasm
Isoform 5: Mitochondrion
Alternative Peptide Names Cgmp-Dependent 3' -5'-Cyclic Phosphodiesterase protein
Cyclic Gmp-Stimulated Phosphodiesterase protein
Cgs-Pde protein
Cgspde protein
PDE2A protein

Information sourced from Uniprot.org

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