| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
PDE2A4 Blocking Peptide is synthetically produced from the 1-50 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
PDE2A |
| Gene ID: |
5138 |
| Uniprot ID: |
PDE2A_HUMAN |
| Immunogen Region: |
1-50 |
| Immunogen: |
Synthetic peptide specific only for PDE2A4 protein. Taken within amino acid region 1-50 on human PDE2A4 protein. |
| Tissue Specificity | Widely expressed. Expressed in brain, with high expression observed in the corpus striatum. Also expressed in heart, placenta, lung, skeletal muscle, kidney and pancreas. |
| Function | cGMP-activated cyclic nucleotide phosphodiesterase with a dual-specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Has a higher efficiency with cGMP compared to cAMP. Plays a role in cell growth and migration. Isoform PDE2A2: Regulates mitochondrial cAMP levels and respiration. Involved in the regulation of mitochondria morphology/dynamics and apoptotic cell death via local modulation of cAMP/PKA signaling in the mitochondrion, including the monitoring of local cAMP levels at the outer mitochondrial membrane and of PKA-dependent phosphorylation of DNM1L. |
| Peptide Name | Cgmp-Dependent 3' -5'-Cyclic PhosphodiesteraseCyclic Gmp-Stimulated PhosphodiesteraseCgs-PdeCgspde |
| Database Links | Reactome: R-HSA-418457Reactome: R-HSA-418555 |
| Cellular Localisation | Isoform Pde2a3: Cell MembraneLipid-AnchorIsoform Pde2a2: Mitochondrion MatrixMitochondrion Inner MembraneMitochondrion Outer MembraneIsoform Pde2a1: CytoplasmIsoform 5: Mitochondrion |
| Alternative Peptide Names | Cgmp-Dependent 3' -5'-Cyclic Phosphodiesterase proteinCyclic Gmp-Stimulated Phosphodiesterase proteinCgs-Pde proteinCgspde proteinPDE2A protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
