| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Phospho-PDE11A Blocking Peptide is synthetically produced from the 75-125 sequence about the S117 and is suitable for use in western blot applications. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
PDE11A |
| Gene ID: |
50940 |
| Uniprot ID: |
PDE11_HUMAN |
| Immunogen Region: |
75-125 |
| Immunogen: |
Synthetic peptide taken within amino acid region 75-125 on PDE11A protein. Phosphorylated Ser 117. |
| Tissue Specificity | Isoform 1 is present in prostate, pituitary, heart and liver. It is however not present in testis nor in penis, suggesting that weak inhibition by Tadalafil (Cialis) is not relevant (at protein level). Isoform 2 may be expressed in testis. Isoform 4 is expressed in adrenal cortex. |
| Function | Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP. Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively. |
| Peptide Name | Dual 3' -5'-Cyclic-Amp And -Gmp Phosphodiesterase 11aCamp And Cgmp Phosphodiesterase 11a |
| Database Links | Reactome: R-HSA-418457Reactome: R-HSA-418555 |
| Cellular Localisation | CytoplasmCytosol |
| Alternative Peptide Names | Dual 3' -5'-Cyclic-Amp And -Gmp Phosphodiesterase 11a proteinCamp And Cgmp Phosphodiesterase 11a proteinPDE11A protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
