PAX5 Blocking Peptide for STJ502155 peptide (STJ504537)

SKU:
STJ504537-250

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Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: PAX5 Blocking Peptide for STJ502155 is synthetically produced from the 1-50 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: PAX5
Gene ID: 5079
Uniprot ID: PAX5_HUMAN
Immunogen Region: 1-50
Specificity: This blocking peptide is recommended for use in combination with PAX5 antibody, STJ502155
Immunogen: Synthetic peptide taken within amino acid region 1-50 on human PAX5 protein.
Post Translational Modifications O-glycosylated. Phosphorylated by SYK. This phosphorylation plays an important role in the abolition of BLIMP1 repression by PAX5 in order to trigger plasma cell differentiation.
Function Transcription factor that plays an essential role in commitment of lymphoid progenitors to the B-lymphocyte lineage. Fulfills a dual role by repressing B-lineage inappropriate genes and simultaneously activating B-lineage-specific genes. In turn, regulates cell adhesion and migration, induces V(H)-to-D(H)J(H) recombination, facilitates pre-B-cell receptor signaling and promotes development to the mature B-cell stage. Repression of the cohesin-release factor WAPL causes global changes of the chromosomal architecture in pro-B cells to facilitate the generation of a diverse antibody repertoire. (Microbial infection) Plays an essential role in the maintenance of Epstein-Barr virus genome copy number within the host cell by promoting EBNA1/oriP-dependent binding and transcription. Participates also in the inhibition of lytic EBV reactivation by modulating viral BZLF1 activity.
Peptide Name Paired Box Protein Pax-5
B-Cell-Specific Transcription Factor
Bsap
Database Links Reactome: R-HSA-8939245
Cellular Localisation Nucleus
Alternative Peptide Names Paired Box Protein Pax-5 protein
B-Cell-Specific Transcription Factor protein
Bsap protein
PAX5 protein

Information sourced from Uniprot.org

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