| Short Description : | PAX4 Blocking Peptide for STJ502153 is synthetically produced from the 250-300 sequence and is suitable for use in western blot applications. |
| Applications: | Immunodepletion/Immunocompetition |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Formulation: | Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | PAX4 |
| Uniprot ID: | PAX4_HUMAN |
| Immunogen: | Synthetic peptide taken within amino acid region 250-300, corresponding to unique amino acid sequence on PAX4 protein. |
| Immunogen Region: | 250-300 |
| Specificity: | This blocking peptide is recommended for use in combination with PAX4 antibody, STJ502153 |
| Function | Plays an important role in the differentiation and development of pancreatic islet beta cells. Transcriptional repressor that binds to a common element in the glucagon, insulin and somatostatin promoters. Competes with PAX6 for this same promoter binding site. Isoform 2 appears to be a dominant negative form antagonizing PAX4 transcriptional activity. |
| Peptide Name | Paired Box Protein Pax-4 |
| Cellular Localisation | Nucleus |
| Alternative Peptide Names | Paired Box Protein Pax-4 proteinPAX4 protein |
Information sourced from Uniprot.org