Tissue Specificity | Expressed in pancreas and in both adult and fetal kidney. Weakly expressed in placenta and lung. Not expressed in other tissues. |
Function | Adapter protein involved in asymmetrical cell division and cell polarization processes. Probably involved in formation of epithelial tight junctions. Association with PARD3 may prevent the interaction of PARD3 with F11R/JAM1, thereby preventing tight junction assembly. The PARD6-PARD3 complex links GTP-bound Rho small GTPases to atypical protein kinase C proteins. |
Peptide Name | Partitioning Defective 6 Homolog BetaPar-6 BetaPar-6b |
Database Links | Reactome: R-HSA-420029Reactome: R-HSA-9013424 |
Cellular Localisation | CytoplasmCell MembraneCell JunctionTight Junction |
Alternative Peptide Names | Partitioning Defective 6 Homolog Beta proteinPar-6 Beta proteinPar-6b proteinPARD6B proteinPAR6B protein |
Information sourced from Uniprot.org