P70 S6 Kinase beta Blocking Peptide for STJ505931 peptide (STJ505718)

SKU:
STJ505718-250

Shipping:
Free Shipping
Current Stock:
Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: P70 S6 Kinase beta Blocking Peptide for STJ505931 is synthetically produced from the 400-450 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: RPS6KB1
Gene ID: 6198
Uniprot ID: KS6B1_HUMAN
Immunogen Region: 400-450
Specificity: This blocking peptide is recommended for use in combination with P70 S6 Kinase beta antibody, STJ505931
Immunogen: Synthetic peptide taken within amino acid region 400-450 on human Ribosomal protein S6 kinase beta protein.
Post Translational Modifications Phosphorylation at Thr-412 is regulated by mTORC1. The phosphorylation at this site is maintained by an agonist-dependent autophosphorylation mechanism. Activated by phosphorylation at Thr-252 by PDPK1. Dephosphorylation by PPP1CC at Thr-412 in mitochondrion.
Function Serine/threonine-protein kinase that acts downstream of mTOR signaling in response to growth factors and nutrients to promote cell proliferation, cell growth and cell cycle progression. Regulates protein synthesis through phosphorylation of EIF4B, RPS6 and EEF2K, and contributes to cell survival by repressing the pro-apoptotic function of BAD. Under conditions of nutrient depletion, the inactive form associates with the EIF3 translation initiation complex. Upon mitogenic stimulation, phosphorylation by the mechanistic target of rapamycin complex 1 (mTORC1) leads to dissociation from the EIF3 complex and activation. The active form then phosphorylates and activates several substrates in the pre-initiation complex, including the EIF2B complex and the cap-binding complex component EIF4B. Also controls translation initiation by phosphorylating a negative regulator of EIF4A, PDCD4, targeting it for ubiquitination and subsequent proteolysis. Promotes initiation of the pioneer round of protein synthesis by phosphorylating POLDIP3/SKAR. In response to IGF1, activates translation elongation by phosphorylating EEF2 kinase (EEF2K), which leads to its inhibition and thus activation of EEF2. Also plays a role in feedback regulation of mTORC2 by mTORC1 by phosphorylating RICTOR, resulting in the inhibition of mTORC2 and AKT1 signaling. Also involved in feedback regulation of mTORC1 and mTORC2 by phosphorylating DEPTOR. Mediates cell survival by phosphorylating the pro-apoptotic protein BAD and suppressing its pro-apoptotic function. Phosphorylates mitochondrial URI1 leading to dissociation of a URI1-PPP1CC complex. The free mitochondrial PPP1CC can then dephosphorylate RPS6KB1 at Thr-412, which is proposed to be a negative feedback mechanism for the RPS6KB1 anti-apoptotic function. Mediates TNF-alpha-induced insulin resistance by phosphorylating IRS1 at multiple serine residues, resulting in accelerated degradation of IRS1. In cells lacking functional TSC1-2 complex, constitutively phosphorylates and inhibits GSK3B. May be involved in cytoskeletal rearrangement through binding to neurabin. Phosphorylates and activates the pyrimidine biosynthesis enzyme CAD, downstream of MTOR. Following activation by mTORC1, phosphorylates EPRS and thereby plays a key role in fatty acid uptake by adipocytes and also most probably in interferon-gamma-induced translation inhibition.
Peptide Name Ribosomal Protein S6 Kinase Beta-1
S6k-Beta-1
S6k1
70 Kda Ribosomal Protein S6 Kinase 1
P70s6k1
P70-S6k 1
Ribosomal Protein S6 Kinase I
Serine/Threonine-Protein Kinase 14a
P70 Ribosomal S6 Kinase Alpha
P70 S6 Kinase Alpha
P70 S6k-Alpha
P70 S6ka
Database Links Reactome: R-HSA-166208
Cellular Localisation Synapse
Synaptosome
Mitochondrion Outer Membrane
Mitochondrion
Colocalizes With Uri1 At Mitochondrion
Isoform Alpha I: Nucleus
Cytoplasm
Isoform Alpha Ii: Cytoplasm
Alternative Peptide Names Ribosomal Protein S6 Kinase Beta-1 protein
S6k-Beta-1 protein
S6k1 protein
70 Kda Ribosomal Protein S6 Kinase 1 protein
P70s6k1 protein
P70-S6k 1 protein
Ribosomal Protein S6 Kinase I protein
Serine/Threonine-Protein Kinase 14a protein
P70 Ribosomal S6 Kinase Alpha protein
P70 S6 Kinase Alpha protein
P70 S6k-Alpha protein
P70 S6ka protein
RPS6KB1 protein
STK14A protein

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance