Niemann Pick C1 Positive Control peptide (STJ504487)

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STJ504487-5
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Applications: WB
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Niemann Pick C1 Positive Control is synthetically produced from the sequence and is suitable for use in western blot applications.
Formulation: Provided as 100 uL ready-to-use, in SDS-PAGE sample buffer (Laemelli's buffer) containing Tris, pH 6.8, 1 % SDS, Glycerol and Bromophenolblue blue as tracking dye. The sample is reduced by adding 2% beta mercaptoethanol. The protein concentration is
Dilution Range: WB: 1:500
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: NPC1
Gene ID: 4864
Uniprot ID: NPC1_HUMAN
Post Translational Modifications N-glycosylated.
Function Intracellular cholesterol transporter which acts in concert with NPC2 and plays an important role in the egress of cholesterol from the endosomal/lysosomal compartment. Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1. Cholesterol binds to NPC1 with the hydroxyl group buried in the binding pocket. Binds oxysterol with higher affinity than cholesterol. May play a role in vesicular trafficking in glia, a process that may be crucial for maintaining the structural and functional integrity of nerve terminals (Probable). Inhibits cholesterol-mediated mTORC1 activation throught its interaction with SLC38A9. (Microbial infection) Acts as an endosomal entry receptor for ebolavirus.
Peptide Name Npc Intracellular Cholesterol Transporter 1
Niemann-Pick C1 Protein
Database Links Reactome: R-HSA-8964038
Cellular Localisation Late Endosome Membrane
Multi-Pass Membrane Protein
Lysosome Membrane
Alternative Peptide Names Npc Intracellular Cholesterol Transporter 1 protein
Niemann-Pick C1 Protein protein
NPC1 protein

Information sourced from Uniprot.org

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