| Applications: |
Immunodepletion/Immunocompetition |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
MRAP2 Blocking Peptide for STJ501796 is synthetically produced from the 70-120 sequence and is suitable for use in western blot applications. |
| Formulation: |
Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice. |
| Storage Instruction: |
Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: |
Mrap |
| Gene ID: |
77037 |
| Uniprot ID: |
MRAP_MOUSE |
| Immunogen Region: |
70-120 |
| Specificity: |
This blocking peptide is recommended for use in combination with MRAP2 antibody, STJ501796 |
| Immunogen: |
Synthetic peptide taken within amino acid region 70-120 on mouse Melanocortin-2 receptor accessory protein. |
| Tissue Specificity | Largely restricted to fat tissues. Predominantly expressed in mouse epididymal (white adipose tissue) and interscapular (brown adipose tissue) fat pads. Expression is weak or absent in lung, spleen, intestine, kidney, heart and skeletal muscle. |
| Function | Modulator of melanocortin receptors (MC1R, MC2R, MC3R, MC4R and MC5R). Acts by increasing ligand-sensitivity of melanocortin receptors and enhancing generation of cAMP by the receptors. Required both for MC2R trafficking to the cell surface of adrenal cells and for signaling in response to corticotropin (ACTH). May be involved in the intracellular trafficking pathways in adipocyte cells. |
| Peptide Name | Melanocortin-2 Receptor Accessory ProteinFat Cell-Specific Low Molecular Weight ProteinFat Tissue-Specific Low Mw Protein |
| Cellular Localisation | Cell MembraneSingle-Pass Membrane ProteinEndoplasmic Reticulum MembraneThe Formation Of Antiparallel Homo- And Heterodimers Suggest That N- And C-Terminus Can Both Localize In The Cytoplasmic And Extracellular PartsDepending On The ContextUpon Insulin StimulationIt Is Redistributed Into Spotty Structures Throughout The Cytoplasm |
| Alternative Peptide Names | Melanocortin-2 Receptor Accessory Protein proteinFat Cell-Specific Low Molecular Weight Protein proteinFat Tissue-Specific Low Mw Protein proteinMrap proteinFalp protein |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
