MR1 Blocking Peptide for STJ506045 peptide (STJ505794)

SKU:
STJ505794-250

£289.50
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Applications: Immunodepletion/Immunocompetition
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: MR1 Blocking Peptide for STJ506045 is synthetically produced from the 155-205 sequence and is suitable for use in western blot applications.
Formulation: Liquid form at 2.5mg/ml concentration in PBS. Up to 5% DMSO can be added. Orders with >1mg can be supplied in lyophilized powder form, or in buffer of choice.
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: MR1
Gene ID: 3140
Uniprot ID: HMR1_HUMAN
Immunogen Region: 155-205
Specificity: This blocking peptide is recommended for use in combination with MR1 antibody, STJ506045
Immunogen: Synthetic peptide taken within amino acid region 155-205 on human Major Histocompatibility Complex Class I related gene protein, isoform 1/MHC I.
Tissue Specificity Ubiquitous. Low expression is detected in peripheral blood B cells, T cells, monocytes and in bronchial epithelial cells (at protein level). Expressed in plasmablasts or plasma B cells in the lamina propria of ileum, appendix and colon (at protein level). Highly expressed on a subset of CD45-positive CD3-positive thymocytes (at protein level).
Post Translational Modifications N-glycosylated.
Function Antigen-presenting molecule specialized in displaying microbial pyrimidine-based metabolites to alpha-beta T cell receptors (TCR) on innate-type mucosal-associated invariant T (MAIT) cells. In complex with B2M preferentially presents riboflavin-derived metabolites to semi-invariant TRAV1-2 TCRs on MAIT cells, guiding immune surveillance of the microbial metabolome at mucosal epithelial barriers. Signature pyrimidine-based microbial antigens are generated via non-enzymatic condensation of metabolite intermediates of the riboflavin pathway with by-products arising from other metabolic pathways such as glycolysis. Typical potent antigenic metabolites are 5-(2-oxoethylideneamino)-6-D-ribitylaminouracil (5-OE-RU) and 5-(2-oxopropylideneamino)-6-D-ribitylaminouracil (5-OP-RU), products of condensation of 5-amino-6-D-ribityaminouracil (5-A-RU) with glyoxal or methylglyoxal by-products, respectively. May present microbial antigens to various TRAV1-2-negative MAIT cell subsets, providing for unique recognition of diverse microbes, including pathogens that do not synthesize riboflavin. Upon antigen recognition, elicits rapid innate-type MAIT cell activation to eliminate pathogenic microbes by directly killing infected cells. During T cell development, drives thymic selection and post-thymic terminal differentiation of MAIT cells in a process dependent on commensal microflora. Acts as an immune sensor of cancer cell metabolome. May present a tumor-specific or -associated metabolite essential for cancer cell survival to a pan-cancer TCR consisting of TRAV38.2-DV8*TRAJ31 alpha chain paired with a TRBV25.1*TRBJ2.3 beta chain on a non-MAIT CD8-positive T cell clone (MC.7.G5), triggering T cell-mediated killing of a wide range of cancer cell types.
Peptide Name Major Histocompatibility Complex Class I-Related Gene Protein
Mhc Class I-Related Gene Protein
Class I Histocompatibility Antigen-Like Protein
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Endoplasmic Reticulum Membrane
Golgi Apparatus Membrane
Early Endosome Membrane
Late Endosome Membrane
In The Absence Of Antigen Remains Within The Endoplasmic Reticulum Where It Acts As A Metabolite Sensor
Antigen Binding Triggers Trafficking Of The Ternary Complex To The Plasma Membrane
After Presentation
Most Of These Complexes Are Rapidly Internalized And Degraded Via Endocytosis
A Small Subset Recycles Via Endosomes Back To The Plasma Membrane And May Thus Acquire And Present New Antigens That Do Not Efficiently Reach The Endoplasmic Reticulum
Isoform 1: Cell Membrane
Single-Pass Membrane Protein
Isoform 3: Cell Membrane
The Larger Proportion Remains In The Er In An Immature State
The Subset That Reach Cell Surface Does It Through A B2m-Independent Pathway
Isoform 4: Secreted
Alternative Peptide Names Major Histocompatibility Complex Class I-Related Gene Protein protein
Mhc Class I-Related Gene Protein protein
Class I Histocompatibility Antigen-Like Protein protein
MR1 protein

Information sourced from Uniprot.org

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