Mouse YKL-40/CHI3L1 (YKL-40/CHI3L1) Antibody Pair (STJAP00839)
General Information
| Short Description | This YKL-40/CHI3L1 antibody pair contains complimentary capture and detection antibodies, which work together under the principals of the. |
| Applications | ELISA |
| Host | Rabbit/Rabbit |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal/Monoclonal |
| Clone ID | R79-6S-2/R34-4Z-7 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Affinity Purified |
| Dilution Range | Determined by end user |
| Formulation | 0.01M PBS, pH 7.2 |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | Chi3l1 |
| Gene ID | 12654 |
| Uniprot ID | CH3L1_MOUSE |
| Immunogen | Recombinant protein |
Additional Info
| Tissue Specificity | Detected in lung in pulmonary macrophages and alveolar type 2 cells and in bronchoalveolar lavage (BAL) fluids. Expressed in mammary tumor cells (at protein level). Expressed in lung. Not detected in non-inflammatory colon. |
| Function | Carbohydrate-binding lectin with a preference for chitin. Has no chitinase activity. May play a role in tissue remodeling and in the capacity of cells to respond to and cope with changes in their environment. Plays a role in T-helper cell type 2 (Th2) inflammatory response and IL-13-induced inflammation, regulating allergen sensitization, inflammatory cell apoptosis, dendritic cell accumulation and M2 macrophage differentiation. Facilitates invasion of pathogenic enteric bacteria into colonic mucosa and lymphoid organs. Mediates activation of AKT1 signaling pathway and subsequent IL8 production in colonic epithelial cells. Regulates antibacterial responses in lung by contributing to macrophage bacterial killing, controlling bacterial dissemination and augmenting host tolerance. Also regulates hyperoxia-induced injury, inflammation and epithelial apoptosis in lung. |
| Protein Name | Chitinase-3-Like Protein 1Brp39 ProteinBreast Regression Protein 39Cartilage Glycoprotein 39Cgp-39Gp-39 |
| Database Links | Reactome: R-MMU-6798695 |
| Cellular Localisation | SecretedExtracellular SpaceCytoplasmEndoplasmic ReticulumDetected In Bronchoalveolar Lavage (Bal) FluidsLocalizes Mainly To Endoplasmic Reticulum When Overexpressed In CellsWith Some Protein Also Detected Throughout The Cytoplasm |
| Alternative Antibody Pair Names | Chitinase-3-Like Protein 1 antibody pairBrp39 Protein antibody pairBreast Regression Protein 39 antibody pairCartilage Glycoprotein 39 antibody pairCgp-39 antibody pairGp-39 antibody pairChi3l1 antibody pairBrp39 antibody pairChil1 antibody pair |
Information sourced from Uniprot.org
Citations
Product Review
Frequently Asked Questions
Common questions about Mouse YKL-40/CHI3L1 (YKL-40/CHI3L1) Antibody Pair (STJAP00839)
This antibody pair is designed to detect mouse YKL-40/CHI3L1, corresponding to UniProt entry Q61362. Reactivity is confirmed for mouse samples only.
Both antibodies are rabbit monoclonal IgGs supplied unconjugated at 1 mg/mL in 0.01M PBS, pH 7.2. The clone IDs are R79-6S-2 and R34-4Z-7, and both have been affinity purified.
This pair is validated for use in ELISA. No other assay formats are listed in the product specifications.
Optimal working dilutions for both antibodies are to be determined by the end user. Titration is recommended when setting up the assay in a specific laboratory context.
Both antibodies should be stored at 4°C for short-term use. For long-term storage, aliquot and store at -20°C, and avoid repeated freeze/thaw cycles to maintain activity.
Both antibodies were raised in rabbit against a recombinant protein immunogen corresponding to mouse YKL-40/CHI3L1. No additional immunogen region details are specified in the product data.
Orders typically arrive within 1 to 2 weeks, and often sooner depending on your location. If your timeline is critical, please contact us before ordering and we can advise on current lead times.
This product is shipped on gel ice packs to maintain integrity during transit. Priority shipping is used as standard to minimise time in transit.
A Certificate of Analysis (CoA) is provided with every order. If you do not receive one, please contact us and we will issue it promptly.