| Applications: |
ELISA |
| Reactivity: |
Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: |
0.134ng/mL |
| Detection Limit: |
0.312-20ng/mL |
| Short Description: |
This VDR Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse tissue homogenates, cell lysates, cell culture supernates or other biological fluids.. |
| Storage Instruction: |
Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: |
4.5 hrs |
| Gene Symbol: |
Vdr |
| Gene ID: |
22337 |
| Uniprot ID: |
VDR_MOUSE |
| Sample Type: |
tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
| Tissue Specificity | |
| Post Translational Modifications | Ubiquitinated by UBR5, leading to its degradation: UBR5 specifically recognizes and binds ligand-bound VDR when it is not associated with coactivators (NCOAs). In presence of NCOAs, the UBR5-degron is not accessible, preventing its ubiquitination and degradation. |
| Function | Nuclear receptor for calcitriol, the active form of vitamin D3 which mediates the action of this vitamin on cells. Enters the nucleus upon vitamin D3 binding where it forms heterodimers with the retinoid X receptor/RXR. The VDR-RXR heterodimers bind to specific response elements on DNA and activate the transcription of vitamin D3-responsive target genes. Plays a central role in calcium homeostasis. Also functions as a receptor for the secondary bile acid lithocholic acid (LCA) and its metabolites. |
| Protein Name | Vitamin D3 ReceptorVdr1 -25-Dihydroxyvitamin D3 ReceptorNuclear Receptor Subfamily 1 Group I Member 1 |
| Database Links | Reactome: R-MMU-196791Reactome: -MMU-383280Reactome: -MMU-4090294 |
| Cellular Localisation | NucleusCytoplasmLocalizes Mainly To The NucleusTranslocated Into The Nucleus Via Both Ligand-Dependent And Ligand-Independent PathwaysLigand-Independent Nuclear Translocation Is Mediated By Ipo4 |
| Alternative ELISA Names | Vitamin D3 Receptor ELISA kitVdr ELISA kit1 -25-Dihydroxyvitamin D3 Receptor ELISA kitNuclear Receptor Subfamily 1 Group I Member 1 ELISA kitVdr ELISA kitNr1i1 ELISA kit |
| output | |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
