| Applications: | ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.064ng/mL |
| Detection Limit: | 0.156-10ng/mL |
| Short Description: | This TSPAN30 Sandwich ELISA Kit, Ready-To-Use is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse plasma, tissue homogenates, cell lysates or other biological fluids.. |
| Storage Instruction: | The whole kit may be stored at-20°C for up to 12 months from receipt. An unopened kit may be stored in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 3 hrs |
| Gene Symbol: | Cd63 |
| Gene ID: | 12512 |
| Uniprot ID: | CD63_MOUSE |
| Immunogen Region: | Ready-To-Use |
| Sample Type: | plasma, tissue homogenates, cell lysates or other biological fluids. |
| Tissue Specificity | Ubiquitous. Strongly expressed in kidney. Detected in spleen, bone marrow, peripheral blood mononuclear cells and macrophages. |
| Post Translational Modifications | Palmitoylated at a low, basal level in unstimulated platelets. The level of palmitoylation increases when platelets are activated by thrombin (in vitro). |
| Function | Functions as a cell surface receptor for TIMP1 and plays a role in the activation of cellular signaling cascades. Plays a role in the activation of ITGB1 and integrin signaling, leading to the activation of AKT, FAK/PTK2 and MAP kinases. Promotes cell survival, reorganization of the actin cytoskeleton, cell adhesion, spreading and migration, via its role in the activation of AKT and FAK/PTK2. Plays a role in VEGFA signaling via its role in regulating the internalization of KDR/VEGFR2. Plays a role in intracellular vesicular transport processes, and is required for normal trafficking of the PMEL luminal domain that is essential for the development and maturation of melanocytes. Plays a role in the adhesion of leukocytes onto endothelial cells via its role in the regulation of SELP trafficking. May play a role in mast cell degranulation in response to Ms4a2/FceRI stimulation, but not in mast cell degranulation in response to other stimuli. |
| Protein Name | Cd63 Antigen Cd Antigen Cd63 |
| Database Links | Reactome: R-MMU-114608 Reactome: -MMU-6798695 |
| Cellular Localisation | Cell Membrane Multi-Pass Membrane Protein Lysosome Membrane Late Endosome Membrane Endosome Multivesicular Body Melanosome Secreted Extracellular Exosome Cell Surface Also Found In Weibel-Palade Bodies Of Endothelial Cells Located In Platelet Dense Granules Detected In A Subset Of Pre-Melanosomes Detected On Intralumenal Vesicles (Ilvs) Within Multivesicular Bodies |
| Alternative ELISA Names | Cd63 Antigen ELISA kit Cd Antigen Cd63 ELISA kit Cd63 ELISA kit |
| output |
Information sourced from Uniprot.org
