Tissue Specificity | Widely expressed. |
Post Translational Modifications | The soluble form is produced from the membrane form by proteolytic processing. |
Function | Binds to FN14 and possibly also to TNRFSF12/APO3. Weak inducer of apoptosis in some cell types. Mediates NF-kappa-B activation. Promotes angiogenesis and the proliferation of endothelial cells. Also involved in induction of inflammatory cytokines. Promotes IL8 secretion. |
Protein Name | Tumor Necrosis Factor Ligand Superfamily Member 12Tnf-Related Weak Inducer Of ApoptosisTweak Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 12 - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 12 - Secreted Form |
Database Links | Reactome: R-MMU-5668541Reactome: -MMU-5676594 |
Cellular Localisation | Cell MembraneSingle-Pass Type Ii Membrane ProteinTumor Necrosis Factor Ligand Superfamily Member 12Secreted Form: Secreted |
Alternative ELISA Names | Tumor Necrosis Factor Ligand Superfamily Member 12 ELISA kitTnf-Related Weak Inducer Of Apoptosis ELISA kitTweak Cleaved Into - Tumor Necrosis Factor Ligand Superfamily Member 12 - Membrane Form - Tumor Necrosis Factor Ligand Superfamily Member 12 - Secreted Form ELISA kitTnfsf12 ELISA kit |
output | |
Information sourced from Uniprot.org