Recombinant Mouse TIMP-1 Protein was determined by SDS-PAGE with Coomassie Blue, showing a band at 30-35 kDa.

Mouse TIMP-1 protein (Recombinant) (C-Avi-His) (STJP003034)

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STJP003034
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Host: HEK293 cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Formulation: Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method: < 0.1 EU/Mu g of the protein by LAL method.
Gene Symbol: Timp1
Gene ID: 21857
Uniprot ID: TIMP1_MOUSE
Immunogen Region: Cys25-Arg205 
Immunogen: Recombinant Mouse TIMP-1 Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Cys25-Arg205 ) of Mouse TIMP-1 (Accession #NP_035723.2) fused with His tag at the C-terminus.
Immunogen Sequence: GAPVANELRCQCLQTVAGIH FKNIQSLKVMPPGPHCTQTE VIATLKNGREACLDPEAPMV QKIVQKMLKGVPK
Tissue Specificity Found in fetal and adult tissues. Highest levels are found in bone. Also found in lung, ovary and uterus.
Post Translational Modifications The activity of TIMP1 is dependent on the presence of disulfide bonds. N-glycosylated.
Function Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling.
Protein Name Metalloproteinase Inhibitor 1
Collagenase Inhibitor 16c8 Fibroblast
Erythroid-Potentiating Activity
Epa
Tpa-S1
Tpa-Induced Protein
Tissue Inhibitor Of Metalloproteinases 1
Timp-1
Database Links Reactome: R-MMU-114608
Reactome: -MMU-1592389
Reactome: -MMU-381426
Reactome: -MMU-8957275
Reactome: -MMU-9839383
Cellular Localisation Secreted
Alternative Protein Names Metalloproteinase Inhibitor 1 protein
Collagenase Inhibitor 16c8 Fibroblast protein
Erythroid-Potentiating Activity protein
Epa protein
Tpa-S1 protein
Tpa-Induced Protein protein
Tissue Inhibitor Of Metalloproteinases 1 protein
Timp-1 protein
Timp1 protein
Timp protein
Timp-1 protein

Information sourced from Uniprot.org

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