| Tissue Specificity | Heart. Up-regulated in the heart in response to ischemic injury and pathology (at protein level). Astrocytes.expressed at high levels in subventricular zone (SVZ)-derived astrocytes and at low levels in cortical astrocytes. In response to peripheral nerve injury, significantly up-regulated in the dorsal spinal cord (at protein level). |
| Function | Adhesive glycoprotein that mediates cell-to-cell and cell-to-matrix interactions and is involved in various processes including cellular proliferation, migration, adhesion and attachment, inflammatory response to CNS injury, regulation of vascular inflammation and adaptive responses of the heart to pressure overload and in myocardial function and remodeling. Binds to structural extracellular matrix (ECM) proteins and modulates the ECM in response to tissue damage, contributing to cardioprotective and adaptive ECM remodeling. Plays a role in ER stress response, via its interaction with the activating transcription factor 6 alpha (ATF6) which produces adaptive ER stress response factors and protects myocardium from pressure overload. May contribute to spinal presynaptic hypersensitivity and neuropathic pain states after peripheral nerve injury. May play a role in regulating protective astrogenesis from the subventricular zone (SVZ) niche after injury in a NOTCH1-dependent manner. |
| Protein Name | Thrombospondin-4 |
| Database Links | Reactome: R-MMU-186797 |
| Cellular Localisation | Endoplasmic ReticulumSarcoplasmic ReticulumSecretedExtracellular SpaceExtracellular Matrix |
| Alternative Protein Names | Thrombospondin-4 proteinThbs4 proteinTsp4 protein |
Information sourced from Uniprot.org
