| Tissue Specificity | Highly expressed in pancreatic islets. Expressed in lung, small interstince, colon, kideny and brain. |
| Post Translational Modifications | |
| Function | Has specific phosphohydrolase activity towards sphingoid base 1-phosphates. Has high phosphohydrolase activity against dihydrosphingosine-1-phosphate and sphingosine-1-phosphate (S1P) in vitro (Probable). Sphingosine-1-phosphate phosphatase activity is needed for efficient recycling of sphingosine into the sphingolipid synthesis pathway. May play a role in attenuating intracellular sphingosine 1-phosphate (S1P) signaling. May play a role in pro-inflammatory signaling. Plays a role in the regulation of pancreatic islet beta-cell endoplasmic reticulum stress and proliferation. |
| Protein Name | Sphingosine-1-Phosphate Phosphatase 2Sppase2Spp2Sphingosine-1-Phosphatase 2 |
| Database Links | Reactome: R-MMU-9845614 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane Protein |
| Alternative ELISA Names | Sphingosine-1-Phosphate Phosphatase 2 ELISA kitSppase2 ELISA kitSpp2 ELISA kitSphingosine-1-Phosphatase 2 ELISA kitSgpp2 ELISA kit |
| output | |
Information sourced from Uniprot.org