| Host: | HEK293 cells |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Conjugation: | Unconjugated |
| Formulation: | Lyophilised from a 0.22 Mu m filtered solution of PBS, pH 7.4. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Determination Method: | < 1 EU/Mu g of the protein by LAL method. |
| Gene Symbol: | Alb |
| Gene ID: | 11657 |
| Uniprot ID: | ALBU_MOUSE |
| Immunogen Region: | Glu25-Ala608 |
| Immunogen: | Recombinant Mouse Serum albumin/ALB Protein is produced by HEK293 cells expression system. The target protein is expressed with sequence (Glu25-Ala608) of mouse Serum albumin/ALB (Accession #NP_033784.2) fused with a 6×His tag at the C-terminus. |
| Immunogen Sequence: | EAHKSEIAHRYNDLGEQHFK GLVLIAFSQYLQKCSYDEHA KLVQEVTDFAKTCVADESAA NCDKSLHTLFGDKLCAIPNL RENYGELADCCTKQEPERNE CFLQHKDDNPSLPPFERPEA EAMCTSFKENPTTFMGHYLH EVARRHPYFYAPELLYYAEQ YNEILTQCCAEADKESCLTP KLDGVKEKALVSSVRQRMKC SSMQKFGERAFKAWAVARLS QTFPNADFAEITKLATDLT |
| Tissue Specificity | Plasma. Expressed in the granular cells within the cerebellum. |
| Post Translational Modifications | Phosphorylated by FAM20C in the extracellular medium. |
| Function | Binds water, Ca(2+), Na(+), K(+), fatty acids, hormones, bilirubin and drugs. Its main function is the regulation of the colloidal osmotic pressure of blood. Major zinc transporter in plasma, typically binds about 80% of all plasma zinc. Major calcium and magnesium transporter in plasma, binds approximately 45% of circulating calcium and magnesium in plasma. Potentially has more than two calcium-binding sites and might additionally bind calcium in a non-specific manner. The shared binding site between zinc and calcium at residue Asp-273 suggests a crosstalk between zinc and calcium transport in the blood. The rank order of affinity is zinc > calcium > magnesium. Binds to the bacterial siderophore enterobactin and inhibits enterobactin-mediated iron uptake of E.coli from ferric transferrin, and may thereby limit the utilization of iron and growth of enteric bacteria such as E.coli. Does not prevent iron uptake by the bacterial siderophore aerobactin. |
| Protein Name | Albumin |
| Database Links | Reactome: R-MMU-114608Reactome: -MMU-159418Reactome: -MMU-189451Reactome: -MMU-189483Reactome: -MMU-2168880Reactome: -MMU-381426Reactome: -MMU-8957275Reactome: -MMU-8964058Reactome: -MMU-9707564Reactome: -MMU-9749641Reactome: -MMU-9757110Reactome: -MMU-9793528 |
| Cellular Localisation | Secreted |
| Alternative Protein Names | Albumin proteinAlb proteinAlb-1 proteinAlb1 protein |
Information sourced from Uniprot.org
