| Applications: | ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 6.8pg/mL |
| Detection Limit: | 15.6-1000pg/mL |
| Short Description : | This SCF Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids.. |
| Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 4.5 hrs |
| Gene Symbol: | Kitlg |
| Gene ID: | 17311 |
| Uniprot ID: | SCF_MOUSE |
| Sample Type: | serum, plasma, tissue homogenates, cell lysates, cell culture supernates or other biological fluids. |
| Tissue Specificity | Expressed in the cochlea. |
| Post Translational Modifications | A soluble form is produced by proteolytic processing of isoform 1 in the extracellular domain. |
| Function | Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins. |
| Protein Name | Kit Ligand Hematopoietic Growth Factor Kl Mast Cell Growth Factor Mgf Steel Factor Stem Cell Factor Scf C-Kit Ligand Cleaved Into - Soluble Kit Ligand Skitlg |
| Database Links | Reactome: R-MMU-1257604 Reactome: -MMU-1433557 Reactome: -MMU-1433559 Reactome: -MMU-5673001 Reactome: -MMU-6811558 Reactome: -MMU-9856649 |
| Cellular Localisation | Isoform 1: Cell Membrane Single-Pass Type I Membrane Protein Isoform 2: Cytoplasm Cytoplasm Cytoskeleton Cell Membrane Cell Projection Lamellipodium Filopodium Soluble Kit Ligand: Secreted |
| Alternative ELISA Names | Kit Ligand ELISA kit Hematopoietic Growth Factor Kl ELISA kit Mast Cell Growth Factor ELISA kit Mgf ELISA kit Steel Factor ELISA kit Stem Cell Factor ELISA kit Scf ELISA kit C-Kit Ligand Cleaved Into - Soluble Kit Ligand ELISA kit Skitlg ELISA kit Kitlg ELISA kit Kitl ELISA kit Mgf ELISA kit Sl ELISA kit Slf ELISA kit |
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Information sourced from Uniprot.org