| Tissue Specificity | Specifically expressed in different metastatic cells. |
| Function | Calcium-binding protein that plays a role in various cellular processes including motility, angiogenesis, cell differentiation, apoptosis, and autophagy. Increases cell motility and invasiveness by interacting with non-muscle myosin heavy chain (NMMHC) IIA/MYH9. Mechanistically, promotes filament depolymerization and increases the amount of soluble myosin-IIA, resulting in the formation of stable protrusions facilitating chemotaxis. Also modulates the pro-apoptotic function of TP53 by binding to its C-terminal transactivation domain within the nucleus and reducing its protein levels. Within the extracellular space, stimulates cytokine production including granulocyte colony-stimulating factor and CCL24 from T-lymphocytes. In addition, stimulates T-lymphocyte chemotaxis by acting as a chemoattractant complex with PGLYRP1 that promotes lymphocyte migration via CCR5 and CXCR3 receptors. |
| Protein Name | Protein S100-A4MetastasinMetastatic Cell ProteinPel98Placental Calcium-Binding ProteinProtein 18a2Protein Mts1S100 Calcium-Binding Protein A4 |
| Database Links | |
| Cellular Localisation | SecretedNucleusCytoplasm |
| Alternative Antibody Pair Names | Protein S100-A4 antibody pairMetastasin antibody pairMetastatic Cell Protein antibody pairPel98 antibody pairPlacental Calcium-Binding Protein antibody pairProtein 18a2 antibody pairProtein Mts1 antibody pairS100 Calcium-Binding Protein A4 antibody pairS100a4 antibody pairCapl antibody pairMts1 antibody pair |
Information sourced from Uniprot.org
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