Mouse ROR1 protein (Recombinant) (C-His) (STJP020297)

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STJP020297-100
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Short Description :Recombinant-Mouse ROR1-C-His protein was developed in hek293 cells using the region Gln30-Tyr406. For use in research applications.
Host:HEK293 cells
Note:STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Conjugation:Unconjugated
Storage Instruction:Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Determination Method:< 1 EU/Mu g of the protein by LAL method.
Gene Symbol:Ror1
Gene ID:26563
Uniprot ID:ROR1_MOUSE
Immunogen:Recombinant Mouse ROR1 Protein is expressed from Expi293 with His tag at the C-terminal.；It contains Gln30-Tyr406.
Immunogen Region:Gln30-Tyr406
Tissue Specificity At postnatal P0, expressed in heart, lung, liver, kidney, spleen and inner ear.
Function Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo. Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling. In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells. Via IGFBP5 ligand, forms a complex with ERBB2 to enhance CREB oncogenic signaling.
Protein Name Inactive Tyrosine-Protein Kinase Transmembrane Receptor Ror1
Mror1
Neurotrophic Tyrosine Kinase - Receptor-Related 1
Database Links Reactome: R-MMU-5140745
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Cell Projection
Axon
Alternative Protein Names Inactive Tyrosine-Protein Kinase Transmembrane Receptor Ror1 protein
Mror1 protein
Neurotrophic Tyrosine Kinase - Receptor-Related 1 protein
Ror1 protein
Ntrkr1 protein

Information sourced from Uniprot.org

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