Mouse RNF43 protein (Recombinant) (N-His) (STJP009853)

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STJP009853
€410.63 - €1,796.88
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Host: E. coli
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Mouse RNF43-N-His protein was developed from e. coli and has a target region of N-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt.
Gene Symbol: Rnf43
Gene ID: 207742
Uniprot ID: RNF43_MOUSE
Immunogen Region: Gln44-Lys189
Immunogen: Mus musculus (Mouse)
Post Translational Modifications Autoubiquitinated.
Function E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway. Along with RSPO2 and ZNRF3, constitutes a master switch that governs limb specification.
Protein Name E3 Ubiquitin-Protein Ligase Rnf43
Ring Finger Protein 43
Ring-Type E3 Ubiquitin Transferase Rnf43
Database Links Reactome: R-MMU-4641263
Cellular Localisation Cell Membrane
Single-Pass Type I Membrane Protein
Endoplasmic Reticulum Membrane
Nucleus Envelope
May Be Secreted
Alternative Protein Names E3 Ubiquitin-Protein Ligase Rnf43 protein
Ring Finger Protein 43 protein
Ring-Type E3 Ubiquitin Transferase Rnf43 protein
Rnf43 protein

Information sourced from Uniprot.org

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