Mouse RNF43 protein (Recombinant) (N-His) (STJP009853)
SPECIFICATIONS
HostE.coli
ImmunogenMus musculus (Mouse)
General Information
| Short Description | Recombinant-Mouse RNF43-N-His protein was developed from e.coli for the region N-His. For use in research applications. |
| Applications | ELISA/Immunogen/SDS-PAGE/WB |
| Host | E.coli |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Dilution Range | Reconstitute in sterile water for a stock solution. |
| Formulation | Lyophilized from a solution in PBS pH 7.4, 0.02% NLS, 1mM EDTA, 4% Trehalose, 1% Mannitol. |
| Storage Instruction | Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for frequent use. Store at-20 to-80°C for twelve months from the date of receipt. |
Target Information
| Gene Symbol | Rnf43 |
| Gene ID | 207742 |
| Uniprot ID | RNF43_MOUSE |
| Immunogen | Mus musculus (Mouse) |
| Immunogen Region | Gln44-Lys189 |
Additional Info
| Post Translational Modifications | Autoubiquitinated. |
| Function | E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination, endocytosis and subsequent degradation of Wnt receptor complex components Frizzled. Acts on both canonical and non-canonical Wnt signaling pathway. Along with RSPO2 and ZNRF3, constitutes a master switch that governs limb specification. |
| Protein Name | E3 Ubiquitin-Protein Ligase Rnf43Ring Finger Protein 43Ring-Type E3 Ubiquitin Transferase Rnf43 |
| Database Links | Reactome: R-MMU-4641263 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinEndoplasmic Reticulum MembraneNucleus EnvelopeMay Be Secreted |
| Alternative Protein Names | E3 Ubiquitin-Protein Ligase Rnf43 proteinRing Finger Protein 43 proteinRing-Type E3 Ubiquitin Transferase Rnf43 proteinRnf43 protein |
Information sourced from Uniprot.org