Mouse RELN/Reelin protein (Recombinant-Active) (C-His) (STJP012144)

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STJP012144-100
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Host: Mammalian Cells
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description : Recombinant-Active-Mouse RELN/Reelin-C-His protein was developed from mammalian cells and has a target region of C-His. For use in research applications.
Formulation: Lyophilized from a solution in PBS pH 7.4, 5% Trehalose, 5% Mannitol.
Dilution Range: Reconstitute in sterile water for a stock solution.
Storage Instruction: Use a manual defrost freezer and avoid repeated freeze thaw cycles. Store at 2 to 8°C for one week. Store at-20 to-80°C for twelve months from the date of receipt.
Endotoxin: <0.1 EU/Mu g of the protein by the LAL method.
Gene Symbol: Reln
Gene ID: 19699
Uniprot ID: RELN_MOUSE
Immunogen Region: Leu1221-Ile2661
Immunogen: Mus musculus (Mouse)
Post Translational Modifications N-glycosylated and to a lesser extent also O-glycosylated.
Function Extracellular matrix serine protease secreted by pioneer neurons that plays a role in layering of neurons in the cerebral cortex and cerebellum by coordinating cell positioning during neurodevelopment. Regulates microtubule function in neurons and neuronal migration. Binding to the extracellular domains of lipoprotein receptors VLDLR and LRP8/APOER2 induces tyrosine phosphorylation of DAB1 and modulation of TAU phosphorylation. Affects migration of sympathetic preganglionic neurons in the spinal cord, where it seems to act as a barrier to neuronal migration. Enzymatic activity is important for the modulation of cell adhesion.
Protein Name Reelin
Reeler Protein
Database Links Reactome: R-MMU-8866376
Cellular Localisation Secreted
Extracellular Space
Extracellular Matrix
Alternative Protein Names Reelin protein
Reeler Protein protein
Reln protein
Rl protein

Information sourced from Uniprot.org

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