Tissue Specificity | |
Post Translational Modifications | The enzyme can be inactivated by further oxidation of the cysteine sulfenic acid (C(P)-SOH) to sulphinic acid (C(P)-SO2H) and sulphonic acid (C(P)-SO3H) instead of its condensation to a disulfide bond. |
Function | Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. Regulates the activation of NF-kappa-B in the cytosol by a modulation of I-kappa-B-alpha phosphorylation. |
Protein Name | Peroxiredoxin-4Antioxidant Enzyme Aoe372Peroxiredoxin IvPrx-IvThioredoxin Peroxidase Ao372Thioredoxin-Dependent Peroxide Reductase A0372Thioredoxin-Dependent Peroxiredoxin 4 |
Database Links | Reactome: R-MMU-6798695 |
Cellular Localisation | CytoplasmEndoplasmic ReticulumNot Secreted |
Alternative ELISA Names | Peroxiredoxin-4 ELISA kitAntioxidant Enzyme Aoe372 ELISA kitPeroxiredoxin Iv ELISA kitPrx-Iv ELISA kitThioredoxin Peroxidase Ao372 ELISA kitThioredoxin-Dependent Peroxide Reductase A0372 ELISA kitThioredoxin-Dependent Peroxiredoxin 4 ELISA kitPrdx4 ELISA kit |
output | |
Information sourced from Uniprot.org