| Applications: | ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Sensitivity: | 0.058ng/mL |
| Detection Limit: | 0.156-10ng/mL |
| Short Description: | This PR3 Sandwich ELISA Kit is an in-vitro enzyme-linked immunosorbent assay for the measurement of samples in mouse serum, plasma, tissue homogenates or other biological fluids.. |
| Storage Instruction: | Store the unopened kit in the fridge at 2-8°C for up to 6 months. Once opened store individual kit contents according to components table provided with the kit. |
| Assay Time: | 4.5 hrs |
| Gene Symbol: | Prtn3 |
| Gene ID: | 19152 |
| Uniprot ID: | PRTN3_MOUSE |
| Sample Type: | serum, plasma, tissue homogenates or other biological fluids. |
| Tissue Specificity | |
| Post Translational Modifications | |
| Function | Serine protease that degrades elastin, fibronectin, laminin, vitronectin, and collagen types I, III, and IV (in vitro). By cleaving and activating receptor F2RL1/PAR-2, enhances endothelial cell barrier function and thus vascular integrity during neutrophil transendothelial migration. May play a role in neutrophil transendothelial migration, probably when associated with CD177. |
| Protein Name | Myeloblastin Proteinase 3 Pr-3 |
| Database Links | Reactome: R-MMU-140875 Reactome: -MMU-6798695 Reactome: -MMU-6803157 |
| Cellular Localisation | Lysosome Secreted Cell Membrane Peripheral Membrane Protein Extracellular Side Membrane Raft Localizes Predominantly To Azurophil Granules (Primary Secretory Granules) In Neutrophils Secreted Upon Neutrophil Stimulation By Tnf-Alpha Lipopolysaccharide (Lps) Fmlp And Cxcl8/Il8 Or During Neutrophil Transmigration Following Secretion Tethered To The Cell Membrane By Cd177 |
| Alternative ELISA Names | Myeloblastin ELISA kit Proteinase 3 ELISA kit Pr-3 ELISA kit Prtn3 ELISA kit |
| output |
Information sourced from Uniprot.org
